Oxidized LDL, a critical factor in atherogenesis☆

Oxidized LDL, a critical factor in atherogenesis.

There is a great deal of experimental, epidemiological, and clinical evidence suggesting that disorders of lipid metabolism play an important role in the pathogenesis of atherosclerosis. To date, there have been many studies investigating the mechanisms by which high levels of LDL-cholesterol affect biology of vessels and cause atherosclerotic lesion formation [1,2]. It has become abundantly cl...

The Dynamics of Oxidized LDL during Atherogenesis

Accumulating evidence indicates that oxidized low-density lipoprotein (OxLDL) is a useful marker for cardiovascular disease. The uptake of OxLDL by scavenger receptors leads to the accumulation of cholesterol within the foam cells of atherosclerotic lesions. OxLDL has many stimulatory effects on vascular cells, and the presence of OxLDL in circulating blood has been established. According to th...

Oxidized LDL and NO Synthesis as Biomarkers of Atherogenesis Correlations with Metabolic Profile in Elderly

Oxidized Ldl Lipids as a Risk Factor for Atherosclerosis

Oxidized LDL-mediated macrophage survival involves elongation factor-2 kinase.

OBJECTIVE Macrophage survival and proliferation is believed to be a contributing factor in the development of early atherosclerotic lesions. Oxidized low density lipoprotein (oxLDL), a key mediator in the pathogenesis of this disease, has been shown to block apoptosis in macrophages deprived of growth factor. In this report, we investigate the mechanism of oxLDL-mediated macrophage survival. ...